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KMID : 0914820100100040168
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Journal of the Korean Gastric Cancer Association
2010 Volume.10 No. 4 p.168 ~ p.174
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Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
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Park Dong-Wook
Lee Kyu-Jae
Jin Sung-Ho
Lee Jae-Hwan
Min Jae-Seok
Park Sun-Hoo
Yu Hang-Jong
Bang Ho-Yoon
Lee Jong-Inn
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Abstract
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Purpose: Infection with Helicobacter pylori is an important risk factor for gastric cancer in humans. We compared the clinicopathologic features of gastric cancer patients based on H. pylori infection.
Materials and Methods: We prospectively studied 155 patients who had gastric cancer and underwent gastrectomies in 1 hospital in Korea. We examined H. pylori infections using the rapid urease test (RUT) with gastrectomy specimens and collected clinical and patho-logic data.
Results: The number of H. pylori infections based on the RUT was 137 (88%). The H. pylori-negative group was significantly associ-ated with AGC and tumor histology. H. pylori infection was significantly correlated with type I/IIa in EGC and type III/IV/V in AGC. AGC was significantly correlated with larger tumor size, lymphatic invasion, perineural invasion, and H. pylori infection based on univariate and multivariate analyses.
Conclusions: We report the prevalence of H. pylori based on the RUT in gastric cancer patients. H. pylori infection influences the tumor histology, progression, and growth type of gastric cancer.
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KEYWORD
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Helicobacter pylori, Stomach neoplasms, Phenotype
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